학력

1996.02 서울대학교(학사)/제약학과

1998.02 서울대학교(석사)/약학과

2001.02 서울대학교(박사)/약학

연구 업적

주요학술논문

Heat Shock Protein 70 in Penile Neurovascular Regeneration Requires Cystathionine Gamma-Lyase, WORLD JOURNAL OF MENS HEALTH, 40권, pp. 580~599, 2022

A novel DDR1 inhibitor enhances the anticancer activity of gemcitabine in pancreatic cancer, AMERICAN JOURNAL OF CANCER RESEARCH, 12권,9호, pp. 4326~4342, 2022

Discovery of a novel NUAK1 inhibitor against pancreatic cancer, BIOMEDICINE & PHARMACOTHERAPY, 152권, pp. 113241, 2022

Lidocaine enhances the efficacy of palbociclib in triple-negative breast cancer, AMERICAN JOURNAL OF CANCER RESEARCH, 12권,7호, pp. 3083~3098, 2022

Combination Therapy of the Active KRAS-Targeting Antibody Inhibitor in Pancreatic Cancer, BIOMOLECULES & THERAPEUTICS, 30권,3호, pp. 274~283, 2022

Comparative analysis of mesenchymal stem cells cultivated in serum free media, SCIENTIFIC REPORTS, 12권,1호, pp. 8620, 2022

Pericyte-derived extracellular vesicle-mimetic nanovesicles ameliorate erectile dysfunction via lipocalin 2 in diabetic mice, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 18권,9호, pp. 3653~3667, 2022

HS-173, a novel PI3K inhibitor enhances radiosensitivity of breast cancer cells, INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 20권,2호, pp. 347~352, 2022

A Serum Marker for Early Pancreatic Cancer With a Possible Link to Diabetes, JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 114권,2호, pp. 228~234, 2022

Pericyte derived extracellular vesicles mimetic nanovesicles improves peripheral nerve regeneration in mouse models of sciatic nerve transection, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 49권, pp. 18, 2022

ANGPTL4 accelerates KRAS(G12D)-Induced acinar to ductal metaplasia and pancreatic carcinogenesis, CANCER LETTERS, 519권, pp. 185~198, 2021

Emerging roles of PHLPP phosphatases in metabolism, BMB REPORTS, 54권,9호, pp. 451~457, 2021

Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape, CANCER LETTERS, 507권, pp. 97~111, 2021

Development and Therapeutic Potential of NUAKs Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 64권,1호, pp. 2~25, 2021

Neutralizing antibody to proNGF rescues erectile function by regulating the e-x-p-r-e-s-s-i-o-n of neurotrophic and angiogenic factors in a mouse model of cavernous nerve injury, ANDROLOGY, 9권,1호, pp. 329~341, 2021

Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury, JOURNAL OF SEXUAL MEDICINE, 18권,1호, pp. 17~28, 2021

Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice, SCIENTIFIC REPORTS, 11권,1호, 2021

MEK blockade overcomes the limited activity of palbociclib in head and neck cancer, TRANSLATIONAL ONCOLOGY, 13권,11호, 2020

Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/MAPK Pathway of Hepatic Stellate Cells, BIOMOLECULES & THERAPEUTICS, 28권,6호, pp. 527~536, 2020

Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity, REDOX BIOLOGY, 37권, 2020

Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse, ANDROLOGY, 8권,5호, pp. 1387~1397, 2020

ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a, EMBO MOLECULAR MEDICINE, 12권,8호, 2020

Artemisiae Iwayomogii Herba Inhibits Growth, Motility, and the PI3K/AKT/mTOR Signaling Pathway in Hepatocellular Carcinoma Cells, PLANTA MEDICA, 86권,10호, pp. 717~727, 2020

HS-146, a novel phosphoinositide 3-kinase alpha inhibitor, induces the apoptosis and inhibits the metastatic ability of human breast cancer cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 56권,6호, pp. 1509~1520, 2020

PBT-6, a Novel PI3KC2 gamma Inhibitor in Rheumatoid Arthritis, BIOMOLECULES & THERAPEUTICS, 28권,2호, pp. 172~183, 2020

SB365 induces apoptosis and suppresses proliferation of glioblastoma cells, INDIAN JOURNAL OF PHARMACOLOGY, 52권,2호, pp. 102~107, 2020

Apoptotic Effects of Xanthium strumarium via PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019권, 2019

Steroidomics for the Prevention, Assessment, and Management of Cancers: A Systematic Review and Functional Analysis, METABOLITES, 9권,10호, 2019

Systemic and Local Metabolic Alterations in Sleep-Deprivation-Induced Stress: A Multiplatform Mass-Spectrometry-Based Lipidomics and Metabolomics Approach, JOURNAL OF PROTEOME RESEARCH, 18권,9호, pp. 3295~3304, 2019

HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer, CANCER LETTERS, 444권, pp. 94~104, 2019

Spheroid-Induced Epithelial-Mesenchymal Transition Provokes Global Alterations of Breast Cancer Lipidome: A Multi-Layered Omics Analysis, FRONTIERS IN ONCOLOGY, 9권, 2019

Metabolomics Approach Based on Multivariate Techniques for Blood Transfusion Reactions, SCIENTIFIC REPORTS, 9권, 2019

A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death, JOURNAL OF GINSENG RESEARCH, 43권,1호, pp. 86~94, 2019

An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer, CANCERS, 11권,2호, 2019

Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study, BIOORGANIC & MEDICINAL CHEMISTRY, 26권,21호, pp. 5596~5611, 2018

Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties, MOLECULES, 23권,10호, 2018

HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, EXPERIMENTAL AND MOLECULAR MEDICINE, 50권, 2018

KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer, CANCER LETTERS, 438권, pp. 174~186, 2018

NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase alpha and its implication in breast cancer cell proliferation, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 22권,9호, pp. 4117~4129, 2018

A systematic review on metabolomics-based diagnostic biomarker discovery and validation in pancreatic cancer, METABOLOMICS, 14권,8호, 2018

A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer, CANCER LETTERS, 426권, pp. 25~36, 2018

An ethyl acetate fraction of Artemisia capillaris (ACE-63) induced apoptosis and anti-angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma, PHYTOTHERAPY RESEARCH, 32권,10호, pp. 2034~2046, 2018

Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-beta/STAT3 Pathway, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 47권,5호, pp. 1751~1768, 2018

Neutrophil elastase in cervical fluid in women with short cervical length, TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 57권,3호, pp. 407~410, 2018

Artemisia Capillaris leaves inhibit cell proliferation and induce apoptosis in hepatocellular carcinoma, BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 18권, 2018

Artemisia capillaris extract AC68 induces apoptosis of hepatocellular carcinoma by blocking the PI3K/AKT pathway, BIOMEDICINE & PHARMACOTHERAPY, 98권, pp. 134~141, 2018

Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer, ONCOTARGET, 8권,68호, pp. 112893~112906, 2017

Identification of 4-Phenoxyquinoline Based Inhibitors for L1196M Mutant of Anaplastic Lymphoma Kinase by Structure-Based Design, JOURNAL OF MEDICINAL CHEMISTRY, 60권,22호, pp. 9205~9221, 2017

Systematic assessment of cervical cancer initiation and progression uncovers genetic panels for deep learning-based early diagnosis and proposes novel diagnostic and prognostic biomarkers, ONCOTARGET, 8권,65호, pp. 109436~109456, 2017

Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery, CANCER LETTERS, 403권, pp. 339~353, 2017

Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin beta 1-drivenSrc-Akt bypass signaling, ONCOGENE, 36권,18호, pp. 2543~2552, 2017

Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 13권,5호, pp. 2043~2049, 2017

Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer, CANCER LETTERS, 396권, pp. 155~166, 2017

NQO1 inhibits proteasome-mediated degradation of HIF-1 alpha, NATURE COMMUNICATIONS, 7권, pp. 13593, 2016

Optimization and biological evaluation of aminopyrimidine-based I kappa B kinase beta inhibitors with potent anti-inflammatory effects, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 123권, pp. 544~556, 2016

HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer, ONCOTARGET, 7권,47호, pp. 78029~78047, 2016

The effect of neutral-surface iron oxide nanopar-ticles on cellular uptake and signaling pathways, INTERNATIONAL JOURNAL OF NANOMEDICINE, 11권, pp. 4595~4607, 2016

Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1 alpha and causes cancer cell death under hypoxia, SCIENTIFIC REPORTS, 6권, 2016

Penile erection induces angiogenic, survival, and antifibrotic signals: molecular events associated with penile erection induced by cavernous nerve stimulation in mice, INTERNATIONAL JOURNAL OF UROLOGY, 23권,7호, pp. 614~622, 2016

Aminoacyl-tRNA synthetase interacting multi-functional protein 1 attenuates liver fibrosis by inhibiting TGF beta signaling, INTERNATIONAL JOURNAL OF ONCOLOGY, 48권,2호, pp. 747~755, 2016

Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats, JOURNAL OF MEDICINAL FOOD, 19권,1호, pp. 38~46, 2016

Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics, EXPERT OPINION ON THERAPEUTIC TARGETS, 19권,10호, pp. 1319~1337, 2015

Effect of adipose-derived stem cell-conditioned medium on the proliferation and migration of B16 melanoma cells, ONCOLOGY LETTERS, 10권, pp. 730~736, 2015

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor b Subunit, Glycoprotein 130, JOURNAL OF IMMUNOLOGY, 195권, pp. 237~245, 2015

Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo, JOURNAL OF KOREAN MEDICAL SCIENCE, 30권,7호, pp. 979~987, 2015

CD-200 induces apoptosis and inhibits Bcr-Abl signaling in imatinib-resistant chronic myeloid leukemia with T315I mutation, INTERNATIONAL JOURNAL OF ONCOLOGY, 47권, pp. 253~261, 2015

Methylation-dependent loss of RIP3 e-x-p-r-e-s-s-i-o-n in cancer represses programmed necrosis in response to chemotherapeutics, CELL RESEARCH, 25권, pp. 707~725, 2015

Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis, ARCHIVES OF PHARMACAL RESEARCH, 38권,5호, pp. 742~751, 2015

HS-543 Induces Apoptosis of Imatinib-Resistant Chronic Myelogenous Leukemia with T315I Mutation, ONCOTARGET, 6권,3호, pp. 1507~1518, 2015

Effects of environmental temperature change on mercury absorption in aquatic organisms with respect to climate warming, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 77권, pp. 1477~1490, 2014

SB365, Pulsatilla saponin D, suppresses the growth of gefitinib-resistant NSCLC cells with Met amplification, ONCOLOGY REPORTS, 32권, pp. 2612~2618, 2014

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy, ONCOTARGET, 5권,20호, pp. 10180~10197, 2014

AAPE proliposomes for topical atopic dermatitis treatment, JOURNAL OF MICROENCAPSULATION, 31권,8호, pp. 768~773, 2014

Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer, ONCOTARGET, 5권,19호, pp. 9150~9168, 2014

Anticancer Activity of HS-527, a Novel Inhibitor Targeting PI3-Kinase in Human Pancreatic Cancer Cells, CANCER LETTERS, 53권,1호, pp. 68~77, 2014

Development and Biological Evaluation of Potent and Selective c-KITD816V Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 57권,15호, pp. 6428~6443, 2014

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin, ONCOTARGET, 5권,12호, pp. 4438~4451, 2014

HS-104, a PI3K inhibitor, enhances anticancer efficacy of gemcitabine in pancreatic cancer, INTERNATIONAL JOURNAL OF ONCOLOGY, 45권, pp. 311~321, 2014

HS-438, a new inhibitor of Imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia, CANCER LETTERS, 348권, pp. 50~60, 2014

Targeted delivery system of nanobiomaterials in anticancer therapy: form cells to clinics, BIOMED RESEARCH INTERNATIONAL, 2014권, pp. 814208, 2014

Combined application of dispersive liquid뻦iquid microextraction based on the solidification of floating organic droplets and charged aerosol detection for the simple and sensitive quantification of macrolide antibiotics in human urine, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 86권, pp. 204~213, 2013

HS-173, a Novel PI3K Inhibitor, Attenuates the Activation of Hepatic Stellate Cells in Liver Fibrosis, SCIENTIFIC REPORTS, 3권, pp. 3470, 2013

Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor, INTERNATIONAL JOURNAL OF ONCOLOGY, 43권, pp. 201~209, 2013

A novel PI3K inhibitor alleviates fibrotic responses in fibroblasts derived from Peyronie's plaques, INTERNATIONAL JOURNAL OF ONCOLOGY, 42권,6호, pp. 2001~2008, 2013

SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells, ONCOLOGY REPORTS, 30권, pp. 801~808, 2013

A formulated red ginseng extract upregulates CHOP and increases TRAIL-mediated cytotoxicity in human hepatocellular carcinoma cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 2013

A novel imidazopyridine PI3K inhibitor with anticancer activity in non-small cell lung cancer cells, ONCOLOGY REPORTS, 30권, pp. 863~869, 2013

Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer, CANCER LETTERS, 2013

Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant, JOURNAL OF MEDICINAL CHEMISTRY, 26권,9호, pp. 3531~3545, 2013

KRC-327, a Selective Novel Inhibitor of c-Met Receptor Tyrosine Kinase with Anticancer Activity, CANCER LETTERS, 331권,2호, pp. 158~166, 2013

KRC-408, a Novel c-Met Inhibitor, Suppresses Cell Proliferation and Angiogenesis of Gastric Cancer, CANCER LETTERS, 332권,1호, pp. 74~82, 2013

SB365, Pulsatilla saponin D targets c-Met and exerts antiangiogenic and anti-tumor activities, CARCINOGENESIS, 2013

Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells, CANCER LETTERS, 328권, pp. 152~159, 2013

Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells, MOLECULAR CANCER THERAPEUTICS, 12권,3호, pp. 274~285, 2013

A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway, CANCER LETTERS, 329권,1호, pp. 59~67, 2013

IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma, CANCER LETTERS, 329권,1호, pp. 99~108, 2013

Antitumor activity of Pulsatilla koreana extract in anaplastic thyroid cancer via apoptosis and anti-angiogenesis, MOLECULAR MEDICINE REPORTS, 7권, pp. 26~30, 2013

HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis, CANCER LETTERS, 328권, pp. 152~159, 2013

Investigation of metabolite alteration in dimethylnitrosamine-induced liver fibrosis by GC-MS, BIOANALYSIS, 5권,1호, pp. 41~51, 2013

SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway, FOOD CHEMISTRY, 136권, pp. 26~33, 2013

Suppression of tumor proliferation and angiogenesis of hepatocellular carcinoma by HS-104, a novel phosphoinositide 3-kinase inhibitor, CANCER LETTERS, 328권, pp. 176~187, 2013

Anticancer effects of KI-10F: A novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer, INTERNATIONAL JOURNAL OF ONCOLOGY, 41권,5호, pp. 1715~1722, 2012

SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway, CANCER SCIENCE, 103권,11호, pp. 1929~1937, 2012

Comparison of oxidized porous silicon with bare porous silicon as a photothermal agent for cancer cell destruction based on in vitro cell test results, LASERS IN MEDICAL SCIENCE, 27권,5호, pp. 1001~1008, 2012

In vitro and in vivo evaluation of N,N,N-trimethylphytosphingosine-iodide (TMP) in liposomes for the treatment of angiogenesis and metastasis, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 434권,1-2, pp. 191~198, 2012

In-vitro cell tests using doxorubicin-loaded polymeric TiO2 nanotubes used for cancer photothermotherapy, ANTI-CANCER DRUGS, 23권,5호, pp. 553~560, 2012

Protective Effect of Fucoidan against Acetaminophen-Induced Liver Injury, ARCHIVES OF PHARMACAL RESEARCH, 35권,6호, pp. 1099~1105, 2012

A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer, CANCER LETTERS, 318권,1호, pp. 68~75, 2012

Design, Synthesis, and Evaluation of 3,5-Disubstituted 7-Azaindoles as Trk Inhibitors with Anticancer and Antiangiogenic Activities, JOURNAL OF MEDICINAL CHEMISTRY, 55권,11호, pp. 5337~5349, 2012

Progress in cancer therapy targeting c-Met signaling pathway, ARCHIVES OF PHARMACAL RESEARCH, 35권,4호, pp. 595~604, 2012

The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells, ARCHIVES OF PHARMACAL RESEARCH, 35권,4호, pp. 747~754, 2012

HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway, CANCER LETTERS, 316권,2호, pp. 187~195, 2012

Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma, INTERNATIONAL JOURNAL OF ONCOLOGY, 40권,2호, pp. 452~460, 2012

In-vivo cancer cell destruction using porous silicon nanoparticles, ANTI-CANCER DRUGS, 22권,10호, pp. 971~977, 2011

소화기질환에서의 줄기세포 치료에 대한 전임상 연구, 대한소화기학회지, 58권,3호, pp. 133~138, 2011

Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells, CANCER LETTERS, 306권,2호, pp. 190~196, 2011

Porous silicon nanoparticles for cancer photothermotherapy, NANOSCALE RESEARCH LETTERS, 6권, 2011

Suppression by Fucoidan of Liver Fibrogenesis via the TGF-beta/Smad Pathway in Protecting against Oxidative Stress, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75권,5호, pp. 833~840, 2011

Design and Synthesis of Imidazopyridine Analogues as Inhibitors of Phosphoinositide 3-Kinase Signaling and Angiogenesis, JOURNAL OF MEDICINAL CHEMISTRY, 54권,7호, pp. 2455~2466, 2011

Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution, BIOORGANIC & MEDICINAL CHEMISTRY, 19권,8호, pp. 2508~2516, 2011

Human Bone Marrow-Derived Clonal Mesenchymal Stem Cells Inhibit Inflammation and Reduce Acute Pancreatitis in Rats, GASTROENTEROLOGY, 140권,3호, pp. 998~1008, 2011

Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach, KIDNEY INTERNATIONAL, 79권,5호, pp. 529~537, 2011

An Effective Assessment of Simvastatin-Induced Toxicity with NMR-Based Metabonomics Approach, PLOS ONE, 6권,2호, 2011

Poloxamer/Cyclodextrin/Chitosan-Based Thermoreversible Gel for Intranasal Delivery of Fexofenadine Hydrochloride, JOURNAL OF PHARMACEUTICAL SCIENCES, 100권,2호, pp. 681~691, 2011

The use of low molecular weight heparin-pluronic nanogels to impede liver fibrosis by inhibition the TGF-beta/Smad signaling pathway, BIOMATERIALS, 32권,5호, pp. 1438~1445, 2011

Identification of Urinary Biomarkers Related to Cisplatin-Induced Acute Renal Toxicity Using NMR-Based Metabolomics, BIOMOLECULES & THERAPEUTICS, 19권,1호, pp. 38~44, 2011

Discovery of new azaindole-based PI3K alpha inhibitors: Apoptotic and antiangiogenic effect on cancer cells, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20권, pp. 7212~7215, 2010

Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer, ONCOLOGY REPORTS, 24권, pp. 957~963, 2010

The Protective Effect of Resveratrol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats, ARCHIVES OF PHARMACAL RESEARCH, 33권, pp. 601~609, 2010

Development of New Fluorescent Xanthines as Kinase Inhibitors, ORGANIC LETTERS, 12권, pp. 1212~1215, 2010

Effect of steam treatment on soluble phenolic content and antioxidant activity of the Chaga mushroom (Inonotus obliquus), FOOD CHEMISTRY, 119권, pp. 619~625, 2010

Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats, JOURNAL OF PINEAL RESEARCH, 48권, pp. 239~250, 2010

Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer, BIOMATERIALS, 31권, pp. 4995~5006, 2010

Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-κB during prevention of oxidative liver injury in a dimethylnitrosamine model, JOURNAL OF PINEAL RESEARCH, 47권, pp. 173~183, 2009

Overe-x-p-r-e-s-s-i-o-n of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24권, pp. 1445~1450, 2009

Proteomic approach to the cytotoxicity of 5-FU in colon cancer cells, 약학회지, 53권, pp. 145~150, 2009

IN-1130, a Novel Transforming Growth Factor-β Type I Receptor Kinase (Activin Receptor-like Kinase 5) Inhibitor, Promotes Regression of Fibrotic Plaque and Corrects Penile Curvature in a Rat Model of Peyronie's Disease, JOURNAL OF SEXUAL MEDICINE, pp. 1284~1296, 2009

Characterization of increased phenolic compounds from fermented Bokbunja (Rubus coreanus Miq.) and related antioxidant activity, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 49권, pp. 820~827, 2009

Protective effect of morin on dimethylnitrosamine (DMN)-induced hepatic fibrosis in rats, DIGESTIVE DISEASES AND SCIENCES, 54권, pp. 782~788, 2009

Proteome changes related to the anti-cancer activity of HT29 cells by the treatment of ginsenoside Rd, PHARMAZIE, 64권, pp. 242~247, 2009

Proteomic analysis of the anti-cancer effect of 20S-ginsenosides Rg(3) in human colon cancer cell lines, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73권, pp. 811~816, 2009

Antioxidant and skin whitening effect of aqueous extracts of Salicornia herbacea, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73권, pp. 552~556, 2009

Reduced Antidiabetic Effect of Metformin and Down-regulation of Hepatic Oct1 in Rats with Ethynylestradiol-Induced Cholestasis, PHARMACEUTICAL RESEARCH, 26권,3호, pp. 549~559, 2009

Anti-Cancer Effect of Betulin on a Human Lung Cancer, PLANTA MEDICA, 75권, pp. 127~131, 2009

Rapid and Simultaneous Determination of Ginsenosides Rb1, Rb2, Rc and Re in Korean Red Ginseng Extract by HPLC using Mass/Mass Spectrometry and UV Detection, Journal of Ginseng Research, 32권,4호, pp. 390~396, 2008

Enhancement in photoluminescence of porous silicon deposited by sputtering an ultrathin silver film, JOURNAL OF THE KOREAN PHYSICAL SOCIETY, 53권,5호, pp. 2562~2567, 2008

Synthesis of Very Straight Bismuth Oxide Nanowires by Using Thermal Evaporation of Bismuth Powders, JOURNAL OF THE KOREAN PHYSICAL SOCIETY, 53권, pp. 1965~1970, 2008

Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons, BRAIN RESEARCH, 1229권, pp. 147~154, 2008

Morin protects acute liver damage by carbon tetrachloride (CCl(4)) in rat, ARCHIVES OF PHARMACAL RESEARCH, 31권,9호, pp. 1160~1165, 2008

Porous silicon as an agent for cancer thermotherapy based on near-infrared light irradiation, JOURNAL OF MATERIALS CHEMISTRY, 18권, pp. 4790~4795, 2008

Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis, ONCOLOGY REPORTS, 20권, pp. 129~134, 2008

Enhanced systemic availability of methotrexate in the presence of morin in rats, BIOPHARMACEUTICS & DRUG DISPOSITION, 29권, pp. 189~193, 2008

Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3), PHARMACOLOGICAL RESEARCH, 56권, pp. 468~473, 2007

Mass spectormetry based proteomic analysis of human stem cells: a brief review, EXPERIMENTAL AND MOLECULAR MEDICINE, 39권, pp. 690~695, 2007

Wondonin, a novel compound, inhibits hypoxia-induced angiogenesis through hypoxia-inducible factor 1 alpha, FEBS LETTERS, 581권, pp. 4977~4982, 2007

Structual basis fr depletion of heat shock protein 90 client proteins by deguelin, JOURNAL OF THE NATIONAL CANCER INSTITUTE, 99권, pp. 949~961, 2007

Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK, BRAIN RESEARCH, 1149권, pp. 76~86, 2007

Determination of proteins in infant milk formula by nano-high performance liquid chromatography-electorospray tandem mass spectrometry, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 845권, pp. 69~73, 2007

Effect of anisomycin on neuronal injury induced by delta-opioid receptor inactivation in cortical neurons, DRUG METABOLISM REVIEWS, 38권, pp. 75~3, 2006

Altered pharmacokinetics and hepatic uptake of TBuMA in ethynylestradio-induced cholestasis, ARCHIVES OF PHARMACAL RESEARCH, 29권, pp. 323~327, 2006

Pharmacokinetics of metformin in ethinylestradiol-induced cholestatic rats, DRUG METABOLISM REVIEWS, 38권, pp. 72~3, 2006

Mechanism for increased bioavailability of tacrine in fasted rats, JOURNAL OF PHARMACY AND PHARMACOLOGY, 58권, pp. 643~649, 2006

Mechanism of intestinal transport of an organic cation, tributylmethylammonium in Caco-2 cell monolayers, ARCHIVES OF PHARMACAL RESEARCH, 29권, pp. 318~322, 2006

Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor, STROKE, 37권,4호, pp. 1094~1099, 2006

Effect of a new hepatoprotective agent, YH-439, on the hepatobiliary transport of organic cations (OCs), ARCHIVES OF PHARMACAL RESEARCH, 2005

Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. Asiatica, ARCHIVES OF PHARMACAL RESEARCH, 28권, pp. 502~508, 2005

Mechanism of the stationary canalicular excretion of tributylmethyl ammonium in rats with a CCl4-induced acute hepatic injury, JOURNAL OF PHARMACEUTICAL SCIENCES, 94권, pp. 317~326, 2005

Profiling of urinary proteins by nano-high performance liquid chromatography/tandem mass spectrometry, JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 28권, pp. 805~822, 2005

Chronic hypoxia-induced upregulation of lactate dehydrogenase (LDH) activity is associated with increased LDH-1 protein e-x-p-r-e-s-s-i-o-n & increases in glycolytic flux in cultured hypoxic neurons, FASEB JOURNAL, 18(4), pp. A211, 2004

Effect of protein kinases on lactate dehydrogenase activity in cortical neurons during hypoxia, BRAIN RESEARCH, 36권, pp. 343~353, 2004

Antioxidant properties of heat-treated Hibiscus syriacus, BIOLOGY BULLETIN, 30권, pp. 15~16, 2003

특허

급성 췌장염 중증도 진단용 정보 제공 방법, 2022

암의 예방 또는 치료용 조성물, 2022

13C 또는 2H 동위원소로 표지된 글라이신을 유효성분으로 포함하는 간암 진단용 조성물, 2022

암의 예방 또는 치료용 조성물, 2022

췌장암 예방 또는 치료용 조성물, 2022

아스프로신을 포함하는 췌장암 진단용 바이오마커 및 이의 인용, 2022

퀴놀린 유도체 및 ALK와 변이된 ALK의 저해제로서의 용도(Quinoline Derivatives and Their Use as ALK and ALK L1196M Inhibitors), 2021

췌장암의 예방 또는 치료용 조성물, 2021

13C 또는 2H 동위원소로 표지된 글라이신을 유효성분으로 포함하는 간암 진단용 조성물, 2021

아스프로신을 포함하는 췌장암 진단용 바이오마커 및 이의 인용, 2021

한인진 추출물을 유효성분으로 포함하는 간암 예방 또는 치료용 조성물(Composition for preventing or treating liver cancer comprising Artemisia iwayomogi Kitamura extract), 2021

급성 췌장염 중증도 진단용 정보 제공 방법, 2021

아스프로신을 포함하는 췌장암 진단용 바이오마커 및 이의 이용, 2020

13C 또는 2H 동위원소로 표지된 글라이신을 유효성분으로 포함하는 간암 진단용 조성물, 2020

신규한 피롤로[2,3-d]피리미딘-4-온 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물(NOVEL PYRROLO[2,3-d]PYRIMIDIN-4-ONE DERIVATIVES AND COMPOSITIONS FOR PREVENTING OR TREATING CANCER CONTAIN, 2020

췌장암 예방 또는 치료용 조성물, 2020

PI3KC2γ를 표적으로 하는 염증 질환 진단 및 치료용 조성물(Composition for diagnosing or treating inflammatory diseases tageting PI3KC2γ), 2020

MMP-10 또는 이를 코딩하는 유전자의 발현을 억제하는 제제를 포함하는 암 전이 억제용 조성물(Composition for suppressing cancer metastasis comprising suppressor of MMP-10 or gene encoding the same), 2020

한인진 추출물을 유효성분으로 포함하는 간암 예방 또는 치료용 조성물, 2019

간질환 예방 또는 치료용 펩타이드 및 이를 유효성분으로 포함하는 조성물, 2019

창이자 추출물의 분획물을 포함하는 간암 예방 또는 치료용 조성물, 2019

PI3-키나제 저해제 및 독소루비신의 복합조성물을 포함하는 항암용 약학조성물 및 이의 제조방법, 2018

PI3KC2γ를 표적으로 하는 염증 질환 진단 및 치료용 조성물, 2018

신규한 피롤로[2,3-d]피리미딘-4-온 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물, 2018

췌장암 진단 또는 치료용 조성물, 2018

인진호 잎 추출물을 유효성분으로 함유하는 간암 예방 또는 치료용 조성물, 2018

MMP-10 또는 이를 코딩하는 유전자의 발현을 억제하는 제제를 포함하는 암 전이 억제용 조성물, 2018

췌장암의 예방 또는 치료용 조성물, 2018

간암 예방 또는 치료용 조성물, 2018

RAS-GTP 타겟 항체 (RT11-i) 및 젬시타빈을 유효성분으로 함유하는 췌장암의 예방 또는 치료용 조성물, 2018

퀴놀린 유도체 및 ALK와 변이된 ALK의 저해제로서의 용도, 2017

PI3-키나제 저해제 및 독소루비신의 복합조성물을 포함하는 항암용 약학 조성물 및 이의 제조방법, 2017

PI3K 및 mTOR 저해제를 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물, 2017

ANGPTL-4 항체를 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물, 2017

이미다조피리딘 유도체를 유효성분으로 포함하는 암 전이 억제용 조성물, 2016

PI3K 저해활성을 갖는 이미다조피리딘 유도체를 유효성분으로 포함하는 관절염의 예방 또는 치료용 조성물, 2016

간질환 예방 또는 치료용 펩타이드 및 이를 유효성분으로 포함하는 조성물, 2016

소라페닙 및 멜라토닌을 유효성분으로 포함하는 췌장암의 예방 또는 치료용 조성물(Composition for preventing or treating pancreatic cancer comprising sorafenib and melatonin), 2016

췌장염 진단용 바이오 마커 조성물, 2015

아자인돌 유도체 화합물, 이를 포함하는 TRK 저해제 조성물 및 TRK와 관련된 질환의 예방 및 치료용 약학 조성물, 2015

소라페닙 및 이미다조피리딘 유도체를 유효성분으로 함유하는 췌장암의 예방 또는 치료용 조성물, 2014

백합나무 추출물을 함유하는 만성 골수성 백혈병 치료용약학적 조성물, 2014

LHP-cRGD를 유효성분으로 포함하는 간경화 예방 또는 치료용 조성물, 2014

이미다조피리딘 유도체, 이를 포함하는 ＰＩ3Ｋ 및/또는 ｍＴＯＲ 저해제용 약학 조성물 및 ＰＩ3Ｋ 및/또는 ｍＴＯＲ과 연관된 질환 치료용 약학 조성물, 2013

잔틴 유도체, 이를 포함하는 ＰＩ３Ｋ 저해제 조성물 및 ＰI３Ｋ와 연관된 질환 치료에 사용되는 조성물, 2013

아자인돌 화합물, 이를 포함하는 ＰＩ３Ｋ 저해제용 약학 조성물 및 ＰI３Ｋ와 연관된 질환 치료용 약학 조성물, 2013

지방줄기세포 유래 단백질 추출물을 안정화시킨 프로리포솜을 유효성분으로 포함하는 아토피성 피부염 치료 또는 예방용 조성물, 2012

줄기세포 배양액을 이용한 암세포 성장 저해 방법 (Inhibition of cancer cell proliferation using adult stem cells culture m, 2008